Our final persistence analyses were all guided by preliminary observations and did not rely on an agnostic approach that could lead to several test problems. In addition, our results correspond to many hypothetical models of AD that describe a process that begins with the intrusion of external antigens into a defective skin barrier and triggers APIs that, in turn, activate the cytokine response associated with the Th2 cell. A well-known function of MHC Class II molecules is the presentation of antigens by APIs to Th2 cells. In addition, since AD is a common disease in all races and ethnicities, it can be expected that a common mechanism (e.g. B class II immunodegregulation) may exist. Finally, it is possible that in some of our samples, the HLA-DRB1 allele was not accurate, because for some of our samples, not all allele ambiguities were resolved. In these cases, we used the most likely avenues. However, 14 of the subjects (23 alleles) that were not fully resolved were also part of the group evaluated by the Omixon software, and for these, the omixon approach was 100% in agreement with this “standard” approach. It is therefore unlikely that it is a source of significant errors. The JDDG publishes scientific work from a variety of disciplines such as dermatology, allergology, phlefology, dermatosurgery, dermatooncology and dermatohistopathology. Also in JDDG: information on medical education, continuing education, calendar of events, book meetings and association announcements. Contributions can be sent in German or English. In the printed version, all articles are published in German.
In the online version, all important articles are published in English. Publons users have indicated that they sit on the editorial board of JDDG: Journal of the Deutsche Dermatologischen Gesellschaft, but we cannot verify these claims. . . .